Check if your application supports the SpaceMouse. There is a list of such applications on the 3Dconnexion site.
Check the information provided by the editor of the application regarding SpaceMouse support.
Verify the SpaceMouse is enabled within your application. Some applications require specific steps to activate a SpaceMouse. Also, you may want to do a “repair” on your 3Dconnexion driver if it was installed before your application.